2-Oxazolidinone, 3-[(2S,3S)-3-hydroxy-2-methyl-4-methylene-1-oxononyl]-4-(1-methylethyl)-, (4S)-
LMT-28
CAS: 1239600-18-0
Molecular Formula: C17H29NO4
2-Oxazolidinone, 3-[(2S,3S)-3-hydroxy-2-methyl-4-methylene-1-oxononyl]-4-(1-methylethyl)-, (4S)- - Names and Identifiers
| Name | LMT-28 |
| Synonyms | LMT-28 2-Oxazolidinone, 3-[(2S,3S)-3-hydroxy-2-methyl-4-methylene-1-oxononyl]-4-(1-methylethyl)-, (4S)- |
| CAS | 1239600-18-0 |
2-Oxazolidinone, 3-[(2S,3S)-3-hydroxy-2-methyl-4-methylene-1-oxononyl]-4-(1-methylethyl)-, (4S)- - Physico-chemical Properties
| Molecular Formula | C17H29NO4 |
| Molar Mass | 311.42 |
| Appearance | oil |
| Color | colorless to light yellow, oil |
| Storage Condition | -20°C |
| In vitro study | LMT-28 reduces IL-6-induced luciferase activity by ~90% at a concentration of 50 μM and exhibits an IC 50 value of 5.9 μM. LMT-28 (1-10 μM; 72 hours) inhibits IL-6-induced proliferation of the human erythroleukemic cell line TF-1. LMT-28 (1-100 μM; 1 hour) selectively inhibits IL-6-induced phosphorylation of STAT3, JAK2, and gp130. Cell Proliferation Assay Cell Line: TF-1 cells (1 ng/mL IL-6-induced) Concentration: 1, 10, 100, 1000, 10000 nM Incubation Time: 72 hours Result: Markedly inhibited IL-6–induced TF-1 proliferation with an IC50 value of 7.5 μM. Western Blot Analysis Cell Line: HepG2 cells (treated with 10 ng/mL IL-6) Concentration: 1, 3, 10, 30, and 100 μM Incubation Time: 1 hour Result: Inhibits IL-6-induced phosphorylation of STAT3, JAK2, and gp130. |
| In vivo study | LMT-28 (0-0.5 mg/kg; p.o.; once daily for 15 days) alleviates CIA in mice. LMT-28 (0.25 or 1 mg/kg; p.o.) ameliorates the progression of pancreatitis in mice. LMT-28 binds directly and specifically to gp130, and thereby inhibits the interaction of gp130 with the IL-6/IL-6Rα complex. Animal Model: Six-week-old male DBA/1J mice (collagen-induced arthritis mice, CIA) Dosage: 0-0.5 mg/kg Administration: Oral; once daily for 15 days Result: Markedly reduced the serum levels of cartilage oligomeric matrix protein (COMP) by 50%, serum amyloid P (SAP) by 55%, and anti-CII IgG by 62%. |
2-Oxazolidinone, 3-[(2S,3S)-3-hydroxy-2-methyl-4-methylene-1-oxononyl]-4-(1-methylethyl)-, (4S)- - Introduction
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Last Update：2024-04-10 22:29:15
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Product Name: LMT-28 Visit Supplier Webpage Request for quotationCAS: 1239600-18-0
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: LMT-28 Visit Supplier Webpage Request for quotationCAS: 1239600-18-0
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: LMT-28 Visit Supplier Webpage Request for quotationCAS: 1239600-18-0
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
View History
2-Oxazolidinone, 3-[(2S,3S)-3-hydroxy-2-methyl-4-methylene-1-oxononyl]-4-(1-methylethyl)-, (4S)-
METHYLENE BIS-BENZOTRIAZOLYL TETRAMETHYLBUTYLPHENOL
Tariquidar methanesulfonate hydrate (XR9576)
N-[(5-CHLORO-2-PHENYL-1H-IMIDAZOL-4-YL)METHYLENE]-3-(TRIFLUOROMETHYL)ANILINE
Isorhamnetin-3-O-robinobioside
ANTI-GLUCOCORTICOID RECEPTOR (AB-1), HUMAN
5-[4-(DIMETHYLAMINO)BENZYLIDENE]-2-PHENYL-3,5-DIHYDRO-4H-IMIDAZOL-4-ONE
3-羟基乙酰苯胺
N-Boc-4-哌啶甲酸
(Val438)-LB24-AB (432-444) (huMan), (Val438)-Monophenol Monooxygenase (432-444) (huMan), (Val438)-SK29-AB (432-444) (huMan), (Val438)-TuMor Rejection Antigen AB (432-444) (huMan)
METHYLENE BIS-BENZOTRIAZOLYL TETRAMETHYLBUTYLPHENOL
Tariquidar methanesulfonate hydrate (XR9576)
N-[(5-CHLORO-2-PHENYL-1H-IMIDAZOL-4-YL)METHYLENE]-3-(TRIFLUOROMETHYL)ANILINE
Isorhamnetin-3-O-robinobioside
ANTI-GLUCOCORTICOID RECEPTOR (AB-1), HUMAN
5-[4-(DIMETHYLAMINO)BENZYLIDENE]-2-PHENYL-3,5-DIHYDRO-4H-IMIDAZOL-4-ONE
3-羟基乙酰苯胺
N-Boc-4-哌啶甲酸
(Val438)-LB24-AB (432-444) (huMan), (Val438)-Monophenol Monooxygenase (432-444) (huMan), (Val438)-SK29-AB (432-444) (huMan), (Val438)-TuMor Rejection Antigen AB (432-444) (huMan)